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| c. 340 BC |
| | | The Macedonians develop the catapult as a siege engine for the armies of Philip II and Alexander the Great | |
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| 337 BC |
| | | The League of Corinth resolves to launch a war against Persia, with Philip II in command of the confederate forces | |
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| 336 BC |
| | | An advance guard of 10,000 troops sets off towards Persia in the spring, with Philip due to follow later with the main army | |
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| 336 BC |
| | | At a summer feast to celebrate the wedding of his daughter, Philip of Macedon is murdered by one of his courtiers | |
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| 336 BC |
| | | The League of Corinth elects Alexander to take his father's place as leader of the campaign against Persia | |
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| 335 BC |
| | | Before departing for the east, Alexander destroys Thebes and enslaves the Thebans for rebelling against the League of Corinth | |
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| 334 BC |
| | | The 21-year-old Alexander the Great marches east with some 5000 cavalry and 30,000 footsoldiers | |
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| 334 BC |
| | | Indulging in a moment of romantic tourism, Alexander visits Troy at the start of his Persian campaign | |
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| 334 BC |
| | | At the river Granicus, not far from Troy, Alexander defeats a Persian army employing many Greek mercenaries | |
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| 333 BC |
| | | At Issus, close to the Turkish border with Syria, Alexander defeats the Persian emperor Darius III, captures his family and treats them with courtesy | |
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